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Molecular Basis of Inheritance

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CBSE Gujarat Board Haryana Board

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Class 10 Class 12

Sickle cell anaemia is

• caused by substitution of valine by glutamic acid in the β-globin chain of haemoglobin

• caused by a change in a base pair of DNA

• characterised by elongated sickle-like RBCs with a nucleus

C.

caused by a change in a base pair of DNA

Sickle-cell anaemia is caused by a change in a single base DNA. It is genetic disease reported from negroes. The individuals of stickle-cell anaemia are immune to malaria.

Sickle-cell anaemia is caused by a change in a single base DNA. It is genetic disease reported from negroes. The individuals of stickle-cell anaemia are immune to malaria.

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Comment two chains of DNA have antiparallel polarity.

The Two chain of DNA are antiparallel that is
if one chain has 5’ x 3’ polarity the other chain has 3’ x 5’ polarity.
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List the function of RNA.

Functions of RNA
RNA acts as genetic material in viruses
It also functions as an adapter and messenger
It also acts as a catalytic molecule and catalyses various biochemical reactions.
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Name the genetic material for majority of organisms.

DNA (Deoxyribose nucleic acid)
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List the number of base pairs in :

(i) lambda bacteriophage

(ii) E.coli and

(iii) haploid content of human DNA.

(i) 48502 bp
(ii) 4.6 x 106 bp and
(iii) 3.3 x 109 bp.
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How many nucleotides are present in a bacteriophage $\mathrm{\varphi }$ x 174.

5386
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