What is antissense technology?  from Biology Molecular Basis of Inheritance Class 12 Nagaland Board
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Molecular Basis of Inheritance

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Class 10 Class 12

What is antissense technology? 

  • A cell displaying a foreign antigen used for synthesis of antigens

  • Production of somaclonal variants in tissue cultures. 

  • When a piece of RNA that is complementary to sequence is used to stop expression of a specific gene.

  • all mutations, whether dominant or recessive are expressed in haploids


C.

When a piece of RNA that is complementary to sequence is used to stop expression of a specific gene.

The antisense RNA technology simply involves the synthesis of RNA molecules that are complementary to the mRNA molecules produced by transcription of a given gene.  Usually t his antisense RNA will not contain the regulatory sequences required for translation but even if does it will not usually specify a functional product. Instead, most antisense RNAs contain multiple termination codons in all three reading frames. However, when antisense RNA molecules are present in the same cytosol with sense (mRNA) molecules of a gene, the antisense RNA and mRNA molecules will anneal to form duplex RNA molecules. These duplex RNA molecules cannot be translated thus, the presence of antisense RNA will block translation of the mRNA of the affected gene.

The antisense RNA technology simply involves the synthesis of RNA molecules that are complementary to the mRNA molecules produced by transcription of a given gene.  Usually t his antisense RNA will not contain the regulatory sequences required for translation but even if does it will not usually specify a functional product. Instead, most antisense RNAs contain multiple termination codons in all three reading frames. However, when antisense RNA molecules are present in the same cytosol with sense (mRNA) molecules of a gene, the antisense RNA and mRNA molecules will anneal to form duplex RNA molecules. These duplex RNA molecules cannot be translated thus, the presence of antisense RNA will block translation of the mRNA of the affected gene.

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List the number of base pairs in :

(i) lambda bacteriophage

(ii) E.coli and

(iii) haploid content of human DNA.


(i) 48502 bp
(ii) 4.6 x 106 bp and
(iii) 3.3 x 109 bp.
757 Views

List the function of RNA.

Functions of RNA
RNA acts as genetic material in viruses
It also functions as an adapter and messenger 
It also acts as a catalytic molecule and catalyses various biochemical reactions.
721 Views

Name the genetic material for majority of organisms.

DNA (Deoxyribose nucleic acid)
965 Views

Comment two chains of DNA have antiparallel polarity.

The Two chain of DNA are antiparallel that is
if one chain has 5’ x 3’ polarity the other chain has 3’ x 5’ polarity.
658 Views

How many nucleotides are present in a bacteriophage ϕ x 174.

5386
805 Views