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During transcription, RNA polymerase holoenzyme binds to a gene promoter and assumes a saddle-like structure, what is it’s DNA-binding sequence?

  • TTAA

  • AATT

  • CACC

  • CACC


D.

CACC

TATA box is present in eukaryotic promotor region. It has a resemblance with pribnow box of prokaryotes. TATA box was identified by Dr. Hogness and so, it is called as Hogness box. It is a 7 bp long region located 20 bp upstream to the start point. During the process of transcription the RNA polymerase (a holoenzyme which has a core unit and sigma factor for proper initiation of transcription) binds to TATA box due to which DNA assumes a saddle-like structure at this place.

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Telomere repetitive DNA sequences control the function of eukaryotic chromosomes because they

  • act as replicons.

  • are RNA transcription initiator

  • help chromosome pairing

  • help chromosome pairing


Differentiation of organs and tissues in a developing organism, is associated with

  • developmental mutations

  • differential expression of genes

  • lethal mutations

  • lethal mutations


Molecular basis of organ differentiation dpends on the modulation in transcription by

  • RNA polymerase

  • ribosome

  • transcription factor

  • transcription factor


The linking of antibiotic resistance gene with the plasmid vector became possible with

  • DNA ligase

  • endonucleases

  • DNA polymerase

  • DNA polymerase


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