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(a) Briefly explain the events of fertilisation and implantation in an adult human female.
(b) Comment on the role of placenta as an endocrine gland.


(a) During coitus, the semen having sperms is released into the vagina.

i. It passes through the cervix of the uterus and reaches the ampullary-isthmic junction of the fallopian tube.

ii. The ovum is also released into the junction for fertilisation to occur.

iii. The process of fusion of the sperm and the ovum is known as fertilisation.

iv. During fertilisation, the sperm induces changes in the zona pellucida and blocks the entry of other sperms. This ensures that only one sperm fertilises an ovum.

v. The enzymatic secretions of the acrosomes help the sperm enter the cytoplasm of the ovum.

vi. This causes the completion of meiotic division of the secondary oocyte, resulting in the formation of a haploid ovum (ootid) and a secondary polar body.

vi. Then, the haploid sperm nucleus fuses with the haploid nucleus of the ovum to form a diploid zygote.

vii. Mitosis starts as the zygote moves through the isthmus of the oviduct (cleavage) and forms 2, 4, 8 and 16 daughter cells called blastomeres.

viii. The 8−16 cell embryo is called a morula, which continues to divide to form the blastocyst. The morula moves further into the uterus.

ix. The cells in the blastocyst are arranged into an outer trophoblast and an inner cell mass.

x. The trophoblast gets attached to the uterine endometrium and the process is called implantation. This leads to pregnancy.

xi. The inner cell mass gets differentiated to form the embryo.

(b) Placenta acts as an endocrine gland and produces the following hormones
i. Human chorionic gonadotropins (hCG), 
ii. human placental lactogen (hPL), 
iii. Estrogen and progesterone
iv. Relaxin (in the later stages of pregnancy).

These hormones support foetal growth and help in the maintenance of pregnancy. Hormones like oestrogen, progestogen, cortisol, thyroxine and prolactin are increased several folds in the maternal blood.

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Identify the correct statement on 'inhibin'

  • is produced by granulosa cells in ovary and inhibits the secretion of FSH

  • is produced by granulosa cells in ovary and inhibits the secretion of LH

  • is produced by nurse cells in testes and inhibits the secretion of LH

  • is produced by nurse cells in testes and inhibits the secretion of LH


(a) Explain the menstrual phase in a human female. State the levels of ovarian and pituitary hormones during this phase.
(b) Why is follicular phase in the menstrual cycle also referred as a proliferative phase ? Explain.
(c) Explain the events that occur in a Graafian follicle at the time of ovulation and thereafter.
(d) Draw a graafian follicle and label antrum and secondary oocyte


Changes in GnRH pulse frequency in females is controlled by circulating levels of

  • estrogen and inhibin

  • progesterone only

  • progesterone and inhibin

  • progesterone and inhibin


(a) Arrange the following hormones in the sequence of their secretion in a pregnant woman.
(b) Mention their source and the function they perform.


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