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According to Hugo de Vries creation and presence of variations are due to mutations. Mutations are sudden, large difference arising suddenly in a population. They effect a large part of gene and can effect any part of it that brings about any change in the gene. Some mutation lead to better adaptation of the species. Thus creation and presence of variation is directionless.
Whereas the natural selection according to Darwin is a slow gradual process in which the nature selects for fitness and leads to speciation in the long run. In natural selection , the  variations for better adaptation which are heritable and which make resource utilisation better for a few species will enable only those to reproduce and leave more progeny. Hence over a period of time, the favored species will become more common and the othespecies will be less common or lost. Thus natural selection is directional in context to adaptation.