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Explain what is meant by metastasis.


Metastasis is the spread of cancer cells to new areas of the body (often by way of the lymph system or bloodstream). The cancerous cells travel to different regions through the blood stream; they lodge at the new sites and start a new tumour. This property is called metastasis.
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What are the various routes by which transmission of human immuno-deficiency virus takes place?


Human immunodeficiency virus or HIV has the following modes of transmission:
(a) Sharing infected needles and syringes.
(b) From an infected mother to a child through the placenta.
(c) Unprotected sexual contact with an infected person.
(d) Transfusion of blood from an infected to a healthy person.




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List the harmful effects caused by alcohol/drug abuse.


Alcohol and drugs have various adverse effects:
Alcohol and drug abuse lead to reckless and rash behaviour, depression, fatigue, aggression and violence.  It has several ill effects on the body, like damage to the liver and the nervous system, loss of weight and appetite, respiratory problems, heart failure, resulting coma and death. Use of needles may lead to transmission of AIDS. Consumption of excess alcohol by any family member can have devastating effects on the family. It leads to several domestic problems such as quarrels, frustrations, insecurity, etc. The person shows rash behaviour, violence, loss of interest in social and other activities. The person becomes a menace for family and society. 

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What is the mechanism by which the AIDS virus causes deficiency of immune system of the infected person?


AIDS (Acquired Immuno Deficiency Syndrome) is caused by the Human immuno-deficiency virus (HIV).  The HIV virus enters the human body by various methods like sharing infected needles, unprotected sexual contact with infected person, or infected blood transfusion. After entering the virus attacks and enters the macrophages. Inside the macrophages, the RNA of the virus is used to produce viral DNA by the process of reverse transcription. The viral DNA integrates itself into the host DNA and directs the synthesis of virus particles. Simultaneously the  HIV enters helper T- lymphocytes and replicates to produce viral progeny there. The cell ruptures and releases newly formed progeny viruses into the blood, attacking other healthy helper T-lymphocytes in the body. As a result, the number of T-lymphocytes in the body of an infected person decreases progressively, thereby decreasing the immunity of a person.
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How is a cancerous cell different from a normal cell?


Normal Cells

Cancerous cells.

1. They have a slow and limited growth.

1. They have a rapid division and are immortal.

2. Contact inhibition present.

2. No contact inhibition is present.

3. Cell growth and differentiation is controlled.

3. Cell growth and differentiation is uncontrolled.

4. Do not show the property of metastasis.

4. Show the property of metastasis.

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