Short Answer TypeHow can bacterial DNA be released from the bacterial cell for biotechnology experiments?
Gene therapy can be used to correct hereditary diseases. It involves delivery of a normal gene into the individual or embryo to take over the function of and compensate for the non-functional gene.
The first clinical gene therapy was given in 1990 to a 4-year old girl with adenosine deaminase (ADA) deficiency. In this disease, the gene coding for enzyme ADA gets deleted leading to deficiency of ADA and problems in immune system. Gene therapy for ADA deficiency includes isolation of lymphocytes from patient’s blood, culturing them in-vitro, introduction of functional ADA cDNA and returning the cells to the patient’s body.
How have transgenic animals proved to be beneficial in:
(a) Production of biological products
(b)Chemical safety testing.
Long Answer TypeWith advancements in genetics, molecular biology and tissue culture, new traits have been incorporated into crop plants. Explain the main steps in breeding a new genetic variety of a crop.
Short Answer Type(a) Mention the cause and the body system affected by ADA deficiency in humans.
(b) Name the vector used for transferring ADA-DNA into the recipient cells in humans. Name the recipient cells.
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