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 Multiple Choice QuestionsMultiple Choice Questions

91.

Match the items in Column I with their uses in Column II and choose the right option.

Column I Column II
A. Bacillus thuringiensis 1. Restriction endonuclease
B. Agrobacterium tumefaciens 2. Thermostable DNA polymerase
C. Thermus aquaticus 3. Insecticidal protein
D. Escherichia coli 4. Tiplasmid

  • A - 3; B - 4; C - 1; D - 2

  • A - 2; B - 1; C - 4; D - 3

  • A - 3; B - 4; C - 1; D - 2

  • A - 1; B - 4; C - 2; D - 3

  • A - 1; B - 4; C - 2; D - 3


E.

A - 3; B - 4; C - 2; D - 1

Column I Column II
A. Bacillus thuringiensis 3. Restriction endonuclease
B. Agrobacterium tumefaciens 4. Thermostable DNA polymerase
C. Thermus aquaticus 2. Insecticidal protein
D. Escherichia coli 1. Tiplasmid

92.

Which one of the following pair is not correct?

  • Mangolian idiocy – 21st chromosome

  • Patau syndrome – 13th chromosome

  • Cri-Du-Chat – 11th chromosome

  • Edward syndrome – 18th chromosome


C.

Cri-Du-Chat – 11th chromosome

Cri-Du-Chat (Cat Cry) Syndrome was first described by Lejeune in 1963 in France. The affected newborn cries-like mewing of a cat. This condition is due to a deletion in the short arm of the chromosome number 5.


93.

Match the items in Column I with their uses in Column II and choose the right option.

Column I Column II
A. ELISA 1. Antigen - antibody interaction
B. PCR 2. Gene amplification
C. Biolistics 3. Direct introduction of recombinant DNA
D. Micro- injection 4. Gold coated DNA

  • A - 3; B - 4; C - 1; D - 2

  • A - 2; B - 1; C - 4; D - 3

  • A - 4; B - 1; C - 2; D - 3

  • A - 1; B - 4; C - 2; D - 3

  • A - 1; B - 4; C - 2; D - 3


E.

A - 1; B - 2; C - 4; D - 3

Column I Column II
A. ELISA 1. Antigen-antibody interaction
B. PCR 2. Gene amplification
C. Biolistics 4. Gold coated DNA
D. Micro-injection 3. Direct introduction of recombinant DNA

94.

Microsatellites are

  • Repetitive DNA sequences

  • ESTs

  • YAC

  • BAC

  • BAC


A.

Repetitive DNA sequences

Every individual organism is unique. DNA sequences have some specific regions in DNA called repetitive DNA. These short nucleotide repeats vary in number from person to person and are called variable number of tandem repeat (VNTR). VNTR belongs to class of satellite DNA referred to as minisatellite. Size of VNTR varies from 1 to 20 bp.


95.

Consider these sentences regarding to the structure and nature of DNA.

(I) DNA has tow pyrimidine bases which contain single ring structure.

(II) In DNA, the composition of bases should be A +TG +C = 1

(III) Each base pair of DNA is 3.4Å apart from the base pair.

(IV) The nucleosome model DNA packaging was proposed by Kornberg and Thomas.

  • I and III

  • I, II and III

  • II, III and IV

  • I, III and IV


D.

I, III and IV

Erwin Chargaff (1950) made quantitative analysis of DNA and showed that the composition of DNA molecules varies in complex ways depending upon the source of DNA. He proposed Base Equivalence rule or Chargaff's rule, which states that for double-stranded DNA, the proportion of adenine always equals to that of thymine and proportion of guanine always equals to that of cytosine.
i.e. A=T and G=C.

It follows that, an equal proportion of purines and pyrimidines is always seen in a double-stranded DNA
i.e.

A + G = T + C or A +GT + C = 1


96.

The Taq polymerase enzyme is obtained from

  • Thiobacillus ferroxidans

  • Bacillus subtilis

  • Pseudomonas subtilis

  • Pseudomonas subtilis


D.

Pseudomonas subtilis

Taq polymerase is a thermostable DNA polymerase obtained from Thermus aquaticus. 

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97.

Which of the following is not a feature of the plasmids?

  • Circular structure

  • Transferable

  • Single stranded

  • Single stranded


C.

Single stranded

Plasmid is extrachromosomal double stranded circular DNA. 

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98.

Which one of the following pair is not correct?

  • Single-stranded DNA

  • Single-stranded RNA

  • Double-stranded DNA

  • None of the above


A.

Single-stranded DNA

Bacteriophage 6 x 174 has single-stranded DNA (ssDNA).


99.

Which of the following is a restriction endonuclease?

  • Protease

  • DNase I

  • RNase

  • RNase


D.

RNase

Hind II is a restriction endonuclease are enzymes used for cutting DNA at specific locations.

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100.

Which one of the following is a reorganization site for restriction enzymeBam HI?

  • 5ʹ– GAATTC – 3ʹ 3ʹ – CTTAAG – 5ʹ

  • 5ʹ – GGATCC – 3ʹ 5ʹ – CCATGG – 3ʹ

  • 5ʹ – GGATCC -– 3ʹ 3ʹ – CCTAGG – 5ʹ

  • 5ʹ– GAATTC – 3ʹ 5ʹ– GTTAAC – 3


C.

5ʹ – GGATCC -– 3ʹ 3ʹ – CCTAGG – 5ʹ